top of page
Selected publications
  1. Nakajo H, Chou MY, Kinoshita M, Appelbaum L, Shimazaki H, Tsuboi T, Okamoto H (2020) Hunger and the orexin-habenula circuit induces winning in social conflicts. Cell Reports. 23;31(12):107790. doi: 10.1016/j.celrep.2020.107790.

  2. Jaggard J,  Lloyd E,  Yuiska A,  Patch A,  Fily Y, Kowalko JE,  Appelbaum L,  Duboue ER,  Keene AC. (2020) Cavefish brain atlases reveal functional and anatomical convergence across independently evolved populations. bioRxiv doi:

  3. Biran J,  Gliksberg M,  Shirat I,  Swaminathan A,  Levitas-Djerbi T,  Appelbaum L,  Levkowitz G (2020) Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior. Scientific Reports. 10:9559. doi: 10.1038/s41598-020-66447-2

  4. Admati I, Wasserman-Bartov Y, Tovin A, Rozenblat R, Blitz E, Zada D, Lerer-Goldshtei T, Appelbaum L (2020) Neural Alterations and Hyperactivity of the Hypothalamic–Pituitary–Thyroid Axis in Oatp1c1 Deficiency. Thyroid 30, 161-174.

  5. Zada D and Appelbaum L (2020) Behavioral criteria and techniques to define sleep in zebrafish. In: Behavioral and Neural Genetics of Zebrafish. 141-153.

  6. Keene AC, Appelbaum L (2019) Sleep in Fish Models. In: Handbook of Behavioral Neuroscience. Elsevier. 30, 363-374.

  7. Levitas-Djerbi T, Sagi D, Lebenthal-Loinger I, Lerer-Goldshtein T, Appelbaum L (2019). Neurotensin Enhances Locomotor Activity and Arousal, and Inhibits Melanin-Concentrating Hormone Signalings. Neuroendocrinology. 2019 Apr 29. doi: 10.1159/000500590

  8. Zada D, Bronshtein I, Lerer-Goldshtein T, Garini Y, Appelbaum L (2019). Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Nature Communication. Mar 5;10(1):895. doi: 10.1038/s41467-019-08806-w.

  9. Dvir H, Elbaz I, Havlin S, Appelbaum L, Ivanov PC, Bartsch RP (2018). Neuronal noise as an origin of sleep arousals and its role in sudden infant death syndrome. Science Advances. Apr 25;4(4):eaar6277. doi: 10.1126/sciadv.aar6277

  10. Eban-Rothschild A, Appelbaum L, de Lecea L (2017). Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology. Apr;43(5):937-952. doi: 10.1038/npp.2017.294.

  11. Levitas-Djerbi T, Appelbaum L (2017). Modeling sleep and neuropsychiatric disorders in zebrafish. Curr Opin Neurobiol. 44:89-93 doi: 10.1016/j.conb.2017.02.017. 

  12. Zada D, Blitz E, Appelbaum L (2017). Zebrafish - An emerging model to explore thyroid hormone transporters and psychomotor retardation. Mol Cell Endocrinol. pii: S0303-7207(17)30172-7. doi: 10.1016/j.mce.2017.03.004. 

  13. Elbaz I, Levitas-Djerbi T, Appelbaum L (2016). The Hypocretin/Orexin Neuronal Networks in Zebrafish. Curr Topics Behav Neuroscience. 2017;33:75-92 doi: 10.1007/7854_2016_59. 

  14. Elbaz I, Zada D, Tovin A, Braun T, Lerer-Goldshtein T, Wang G,  Mourrain P, Appelbaum L (2016). Sleep-Dependent Structural Synaptic Plasticity of Inhibitory Synapses in the Dendrites of Hypocretin/Orexin Neurons. Molecular Neurobiology. 

  15. Zada D, Tovin A, Lerer-Goldshtein T, Appelbaum L  (2016). Pharmacological and BBB-targeted genetic therapies for thyroid hormone-dependent hypomyelination. Disease Models & Mechanisms.  pii: dmm.027227. 

  16. Shamay-Ramot A, Khermesh K, Porath HT, Barak M, Pinto Y, Wachtel C, Zilberberg A, Lerer-Goldshtein T, Efroni S, Levanon EY, and Appelbaum L (2015). Fmrp interacts with Adar and regulates RNA editing, synaptic density and locomotor activity in zebrafish. PLoS Genet. 11:e1005702.

  17. Yelin-Bekerman L, Elbaz I, Diber A, Dahary D, Gibbs-Bar L, Alon S, Lerer-Goldshtein T, Appelbaum L. (2015). Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a. eLife. 4. pii: e08638. 

  18. Oren M, Tarrant AM, Alon S, Simon-Blecher N, Elbaz I, Appelbaum L and Levy O. (2015). Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Scientific reports. 5:11418. 

  19. Levitas-Djerbi T, Yelin-Bekerman L, Lerer-Goldshtein T, Appelbaum L.(2015). The Hypothalamic Leptin-Neurotensin-Hypocretin Neuronal Networks in Zebrafish. J Comp Neurol. 523:831-848. 

  20. Elbaz I, Lerer-Goldshtein T, Okamoto H, Appelbaum L. (2015).  Reduced synaptic density and deficient locomotor response in neuronal activity-regulated pentraxin 2a mutant zebrafish. FASEB J.  29:1220-34. 

  21. Zada D, Tovin A, Lerer-Goldshtein T, Vatine GD, Appelbaum L. (2014). Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation. PLoS Genet 10:e1004615. 

  22. Sharaby Y, Lahmi R, Amar O, Elbaz I, Lerer-Goldshtein T, Weiss AM, Appelbaum L, Tzur A. (2014). Gas2l3 is essential for brain morphogenesis and development. Dev Biol. 394:305-13. 

  23. Oren M, Brikner I, Appelbaum L, Levy O. (2014). Fast neurotransmission related genes are expressed in non nervous endoderm in the sea anemone Nematostella vectensis. PLoS One. 9:e93832.  

  24. Elbaz, I., Foulkes, N.S., Gothilf, Y., and Appelbaum, L. (2013). Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish. Frontiers in Neural Circuits 7:9.​ 

  25. Vatine, G.D., Zada, D., Lerer-Goldshtein, T., Tovin, A., Malkinson, G., Yaniv, K., and Appelbaum, L. (2013). Zebrafish as a model for monocarboxyl transporter 8-deficiency. J Biol Chem 288, 169-180.​ 

  26. Elbaz I, Yelin-Bekerman L, Nicenboim J, Vatine G, and Appelbaum L (2012) Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish. The Journal of Neuroscience 32:12961–12972.​ 

  27. Wang G, Grone B, Colas D, Appelbaum L and Mourrain P (2011) Synaptic plasticity in sleep: learning, homeostasis and disease. Trends in Neurosciences. 34:452-63.​ 

  28. Appelbaum L, Wang G, Yokogawa T, Skariah G, Smith SJ, Mourrain P and Mignot E (2010) Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron. 68:87-98 (cover)*.​ *This paper was highlighted in Nature: Neuroscience: Brain connections have rhythm. Nature 468: 349.​

  29. Appelbaum L, Wang G, Maro G, Mori R, Tovin A, Marin W, Yokogawa Y, Kawakami K, Smith SJ, Gothilf Y, Mignot EM and Mourrain P (2009). Sleep/wake regulation and hypocretin-melatonin interaction in zebrafish. Proceedings of the National Academy of Sciences U S A. 106:21942-21947 (track II). ​

  30. Vatine G, Vallone D, Appelbaum L, Mracek P, Ben-Moshe Z, Lahiri K, Gothilf Y and Foulkes NS (2009) Light directs zebrafish period2 expression via conserved D and E boxes. PLoS Biology. 7:e1000223. 

  31. Levy O, Appelbaum L, Leggat W, Gothlif Y, Hayward DC, Miller DJ and Hoegh-Guldberg O (2007) Light-responsive cryptochromes from the simplest marine eumetazoan animals. Science. 318: 467-470.​

  32. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, Rosa F, Mourrain P and Mignot E (2007) Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biology. 5: 2379-2397.​

  33. Appelbaum L, Skariah G, Mourrain P and Mignot E (2007) Purinergic transmission by P2X receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. Brain Research. 1174: 66-75.​

  34. Zilberman-Peled* B, Appelbaum* L, Vallone D, Foulkes NS, Anava S, Anzulovich A, Coon SL, Klein DC, Falcon J,  Ron B and Gothilf Y (2007) Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. Journal of Neuroendocrinology. 19:46-53. *Equally contributed.​

  35. Faraco* JH, Appelbaum* L, Marin W, Gaus S, Mourrain P, Mignot E (2006) Regulation of hypocretin (orexin) expression in embryonic zebrafish. Journal of Biological Chemistry. 281: 29753-61. *Equally contributed. 

  36. 18 Appelbaum L, Gothilf Y (2006) Mechanism of pineal-specific gene expression: The role of E-box and photoreceptor conserved elements. Molecular and Cellular Endocrinology. 252: 27-33. ​

  37. Appelbaum L, Vallone D, Anzulovich A, Ziv L, Tom M, Foulkes N, Gothilf Y (2006) Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of circadian-clock. Journal of Molecular Endocrinology. 36: 337-347. 

  38. Appelbaum L, Anzulovich A, Baler R, Gothilf Y (2005) Homeobox-clock protein interaction in zebrafish: A shared mechanism for pineal-specific and circadian gene expression. Journal of Biological Chemistry 280: 11544–11551.​

  39. Appelbaum L, Toyama R, Dawid IB, Klein DC, Baler R, Gothilf Y (2004) Zebrafish serotonin-N-acetyltransferase-2 gene regulation: Pineal-restrictive downstream module (PRDM) contains a functional E-box and three photoreceptor conserved elements. Molecular Endocrinology 18: 1210-1221.​

  40. Appelbaum L, Achituv Y, Mokady O (2002) Speciation and the establishment of zonation in an intertidal barnacle - specific settlement versus selection. Molecular Ecology 11: 1731-1737.


bottom of page